Efficacy of preoxygenation administration in volunteers, in extending the end-expiration breath-hold duration for application to abdominal radiotherapy

Efficacy of preoxygenation administration in volunteers, in extending the end-expiration breath-hold duration for application to abdominal radiotherapy

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Background and purpose: End expiration breath hold (EEBH) is the preferred motion management method for abdominal Stereotactic Ablative Body Radiotherapy (SABR) treatments.However, multiple short EEBHs are required to complete a single treatment strikketøy oppbevaring session.The study aimed to determine the efficacy of preoxygenation with hyperventilation in extending an EEBH duration.

Materials and methods: We randomised 10 healthy participants into two arms, each included breathing room air and oxygen at a rate of 10 L per minute (l/min) without hyperventilation for four minutes, and normally for four minutes and with hyperventilation for one minute at a rate of 20 breaths/minute for hyperventilation.The type of gas was blinded from the participants for each test.EEBH durations were then recorded, as well as systolic blood pressure, SpO2 and heart rate.

A discomfort rating was also recorded after each breath hold.Results: A significant increase in duration of almost 50% was observed between normal breathing of room air and breathing oxygen normally followed by hyperventilation.Vital wac 4011 signs remained consistent between the 4 tests.

The tests were well tolerated with 75% of participants recording none or minimal discomfort.Conclusion: Preoxygenation with hyperventilation could be used to increase the EEBH duration for abdominal SABR patients which would assist in the accuracy of these treatments and possibly resulting in a reduction of overall treatment times.